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Gene Targeting and Transgenic Facility

The Gene Targeting and Transgenic Facility (GTTF) at UConn Health provides design and generation of genetically modified mice and other services.

GTTF mice on the cover!

Cover of JBC

Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S., (2016). Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis and Bone Resorption. J. Biol. Chem. 291: 1538-1551.

Mice harboring a gain-of-function Notch2 mutation recapitulate selected skeletal manifestations of Hajdu-Cheney syndrome. Image of a femoral cross-section (bone marrow cells in green, bone surface with osteoblasts in purple and red, osteoclasts in yellow) from a mutant mouse.

CRISPR mice now available in the GTTF!